Intro

Killing the parasite slowly but surely!

Fenbendazole has been shown to effectively trigger apoptosis and halt the cell cycle at the G2/M phase in both standard and drug-resistant cancer cells. In studies involving 5-fluorouracil-resistant SNU-C5 cells, these cells exhibited reduced autophagy but a notable increase in ferroptosis—an iron-dependent form of cell death—which also appeared to enhance the apoptotic process. Interestingly, these resistant cells showed lower activation of caspase-8 and p53, key proteins often involved in cancer cell death. This suggests that fenbendazole's powerful anticancer effects may operate independently of p53, making it a promising alternative approach for treating cancers that no longer respond to conventional chemotherapy like 5-fluorouracil. Let's kill cancer!!!